YC_BS1

The main aim of this project was to explore to what extent genetic and environmental factors explain individual differences in brain development and cognition. The study was the start of a Dutch longitudinal study in which twins, their siblings and their parents were assessed at three year intervals. Data collection included psychometric IQ tests, a comprehensive neuropsychological testing protocol, and parental and self-ratings of behavioral and emotional problems. Physical maturation was measured through assessment of Tanner stages. Hormonal levels (cortisol, luteinizing hormone, follicle-stimulating hormone, testosterone, and estrogens) were assessed in urine and saliva. Brain scans were acquired using 1.5 Tesla Magnetic Resonance Imaging (MRI), which provided volumetric measures and measures of cortical thickness. Buccal swabs were collected for DNA isolation for future candidate gene and genome-wide analysis studies

Cohort
Subject age
  • 9.0 years
Time span From 2005-01-01 to 2005-01-01
Geographic location NL
Publisher
Creators
Dorret I. Boomsma
Vrije Universiteit Amsterdam
Contributors
Marieke van Leeuwen
Vrije Universiteit Amsterdam
Jisca Peper
Vrije Universiteit Amsterdam
Funding information
NWO
051.02.060
NWO
051.02.061
NWO/SPI
56-464-14192
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