YC_ADHMRI

Within the ADHD-MRI project, the genetic and environmental influence on ADHD related neurobiological changes were investigated in monozygotic twins. Twins were selected based on their Child Behavior Checklist Attention Problems (CBCL-AP) scores obtained in the regular YNTR survey waves and divided into three groups: discordant pairs (one affected, one unaffected), concordant pairs (both affected) and control pairs (both unaffected). To determine the presence of ADHD, mothers of the participants were interviewed with the Diagnostic Interview Schedule for Children (DISC-IV). Additionally, they filled in two behavioral questionnaires (CBCL and Strengths and Weaknesses of ADHD Symptoms and Normal Behavior (SWAN)). The twins filled in the Youth Self Report (YSR). Based on the outcome of the interview and questionnaires, twin pairs that were found eligible for the MRI experiments were invited. Both structural and functional MRI (color-stroop and flanker tasks) were performed. DNA was collected to confirm zygosity.

Cohort
Subject age
  • 15.0 years
Time span From 2003-01-01 to 2007-01-01
Geographic location NL
Publisher
Creators
Dorret I. Boomsma
Vrije Universiteit Amsterdam
Contributors
Eske M. Derks
Vrije Universiteit Amsterdam
Funding information
NIMH RO1
MH58799-03
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