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measure Inflammation markers
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Main Cohort Early pregnancy Mid pregnancy 5-6 years 9-10 yearsInflammation markers, for instance C-reactive protein (CRP), Lymphocytes, Neopterin, Immunoglobulin E (IgE), Immunoglobulin G (IgG), and tissue Transglutaminase Immunoglobulin A (tTg-IgA), measured with traditional enzymatic tests, such as Enzyme-Linked Immunosorbent Assays (ELISA).Created May 3, 2023 • Updated May 3, 2023 -
measure Lipids
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Main Cohort Early pregnancy 5-6 years 9-10 yearsLipids, for instance Cholesterol, Triglycerides, Low-Density Lipoprotein Cholesterol (LDL-C), High-Density Lipoprotein Cholesterol (HDL-C), Lipoproteins, and Apolipoproteins measured with traditional enzymatic tests, such as Enzyme-Linked Immunosorbent Assays (ELISA).Created May 3, 2023 • Updated May 3, 2023 -
measure LC-MS lipidomics
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Main Cohort Early pregnancy 9-10 yearsLiquid chromatography mass spectrometry (LC-MS) platform targeting lipid species.Created May 3, 2023 • Updated May 3, 2023 -
measure Saliva sample
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Main Cohort 1.5 years 5-6 years 9-10 yearsHPA axis, Cortisol diurnal rhythm (@home) and stress reaction (@lab) @14 months, subgroupCreated May 3, 2023 • Updated May 3, 2023 -
measure LC-MS amines
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Main Cohort Early pregnancy 9-10 yearsLiquid chromatography mass spectrometry (LC-MS) platform targeting amines.Created May 3, 2023 • Updated May 3, 2023 -
measure Hair sample
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Main Cohort 5-6 years 9-10 years 13-14 yearsA hair sample was obtained at age 6 to quantify several sex steroids, including cortisol, cortisone, 17OHP, androstenedione, testosterone and DHEAS. 3cm samples were taken from 100-200 hairs close to the scalp.Created May 3, 2023 • Updated May 3, 2023 -
measure GC-MS organic acids
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB1_1 YC_ACTIONBB1_2 YC_ACTIONBB2 YC_ACTIONBB3Gas chromatography mass spectrometry (GC-MS) platform targeting organic acids.Created March 28, 2023 • Updated April 4, 2023 -
measure Urine osmolality
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB1_1 YC_ACTIONBB1_2 YC_ACTIONBB2 YC_ACTIONBB3Urinary osmolality as measured with density test (specific gravity) using the Atago refractometer PAL-10S BLT/A+W (Atago, Tokyo, Japan). The refractive index is a ratio of the velocity of light in air to the velocity of light in solution, which is directly proportional to the number of dissolved solids in urine.Created March 28, 2023 • Updated April 4, 2023 -
measure Peptide hormones
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB1_1 YC_ACTIONBB1_2 YC_BS1 YC_BS2 YC_BS3Peptide hormones, for instance Adrenocorticotropic Hormone (ACTH, pituitary hormone), Alpha-Melanocyte-Stimulating Hormone (α-MSH, Melanocortin), Luteinizing Hormone (LH), Cholecytokinin, and Follicle Stimulating Hormone (FSH), measured with traditional enzymatic tests, such as Enzyme-Linked Immunosorbent Assays (ELISA).Created March 28, 2023 • Updated April 4, 2023 -
measure Liver enzymes
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB1_1 YC_ACTIONBB1_2 YC_ACTIONBB2 YC_ACTIONBB3 YC_BS1 YC_BS2 YC_BS3Liver enzymes, for instance Albumin, Jodide, Aspartaat Aminotransferase (ASAT), and Alanine Transaminase (ALAT), measured with traditional enzymatic tests, such as Enzyme-Linked Immunosorbent Assays (ELISA).Created March 28, 2023 • Updated April 4, 2023 -
measure Oxidative stress markers
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB1_1 YC_ACTIONBB1_2 YC_ACTIONBB2 YC_ACTIONBB3Oxidative stress markers, including Oxidized DNA/RNA, Total Antioxidant Capacity, and Thiobarbituric acid reactive substances (malondialdehyde), measured with traditional enzymatic tests, such as Enzyme-Linked Immunosorbent Assays (ELISA).Created March 28, 2023 • Updated April 4, 2023 -
measure Inflammation markers
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB1_1 YC_ACTIONBB1_2 YC_ACTIONBB2 YC_ACTIONBB3Inflammation markers, for instance C-reactive protein (CRP), Lymphocytes, Neopterin, Immunoglobulin E (IgE), Immunoglobulin G (IgG), and tissue Transglutaminase Immunoglobulin A (tTg-IgA), measured with traditional enzymatic tests, such as Enzyme-Linked Immunosorbent Assays (ELISA).Created March 28, 2023 • Updated April 4, 2023 -
measure Viral infections
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB1_1 YC_ACTIONBB1_2 YC_ACTIONBB2Viral and parasitic infection loads, for instance Influenza A, Influenza B, Herpes Simplex Virus 1 (HSV1), Herpes Simplex Virus 2 (HSV2), Toxoplasma Gondii, Cytomegalovirus (CMV), Epstein-Barr Virus (EBV), and Procalcitonin, measured with traditional enzymatic tests, such as Enzyme-Linked Immunosorbent Assays (ELISA).Created March 28, 2023 • Updated April 4, 2023 -
measure DNA methylation (array)
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB3Assessment of DNA methylation as obtained through DNA methylation arrays.Created March 28, 2023 • Updated April 4, 2023 -
measure LC-MS amines
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB1_1 YC_ACTIONBB1_2 YC_ACTIONBB2 YC_ACTIONBB3Liquid chromatography mass spectrometry (LC-MS) platform targeting amines.Created March 28, 2023 • Updated April 4, 2023 -
measure LC-MS steroid hormones
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB2 YC_ACTIONBB3 YC_BS1Liquid chromatography mass spectrometry (LC-MS) platform targeting steroid hormones.Created March 28, 2023 • Updated April 4, 2023 -
measure Genotyping (array)
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB1_1 YC_ACTIONBB1_2 YC_ACTIONBB2 YC_ACTIONBB3 YC_BS1 YC_BS2 YC_BS3 YC_DSC YE_FITNSS YC_ADHMRI YE_COG18Assessment of single nucleotide polymorphisms (SNPs) as obtained through genotyping arrays.Created March 28, 2023 • Updated April 4, 2023 -
measure Neuropeptides
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB1_1 YC_ACTIONBB1_2 YC_ACTIONBB2 YC_ACTIONBB3Neuropeptides, including Substance P, Beta-endorphin, Dynorphin A, neurotensin, and Leu-enkaphalin, measured with traditional enzymatic tests, such as Enzyme-Linked Immunosorbent Assays (ELISA).Created March 28, 2023 • Updated April 4, 2023 -
measure Buccal swab
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB1_1 YC_ACTIONBB1_2 YC_ACTIONBB2 YC_ACTIONBB3 YC_BS1 YC_BS2 YC_BS3 YC_DSC YE_FITNSS YE_ATTEF1 YE_ATTEF2 YE_ATTEF3 YC_ADHMRI YE_COG18Cheek swabs were obtained by rubbing buds along the inside of the mouth to obtain buccal cell scrapings.Created March 28, 2023 • Updated April 4, 2023 -
measure Dipstick
Study: NTR Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Young Netherlands Twin Register YC_ACTIONBB1_1 YC_ACTIONBB1_2 YC_ACTIONBB2 YC_ACTIONBB3Urinary dipstick (Siemens, Marburg, Germany) was applied to the first thaw of the urine samples either by dipping in the residual urine volume after aliquoting or by dropping urine on the dipstick to screen for signs of infections in the urine and to measure leukocytes, nitrite, proteins, glucose, and blood presence in the urine.Created March 28, 2023 • Updated April 4, 2023